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Novel Ultrasound Techniques combined with Immuno therapy to treat Solid Tumors 
Tuesday, 26 November 2019,  3:00 -  5:00
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Novel Ultrasound Techniques combined with Immuno therapy to treat Solid Tumors

by

Avinash Eranki, Ph.D

Senior Research and Development Engineer

Fairfax, National Institutes of Health & Children’s National, USA

 

Cancerous solid tumors are extremely debilitating and one of the rising and common cause for mortality.  Neuroblastoma is the most common extracranial cancer, and accounts for about 15% of all pediatric cancer fatalities. Despite a multimodal treatment approach, the overall survival is unacceptably poor in these patients. Check point inhibition therapy recently led to remarkable clinical advances in cancer therapy, however, benefits a small percentage of patients.In this talk, I will describe the benefit of paradigm shifting non-invasive High Intensity focused ultrasound (HIFU) technology to treat solid tumors in both pediatric and adult populations. I will also explain as to how this technology can be translated to the clinic, and potentially lead to improved outcomes. Our institution currently has multiple funded clinical trials (NCT02349971, NCT02536183, NCT02076906) using HIFU alone or in combination with targeted-liposomal chemotherapy to treat pediatric solid tumors. Based on this clinical experience, we have further developed newer and spatially precise HIFU techniques, which when combined with commercially available check point inhibitors, lead to significantly improved outcomes in a large and refractory model of neuro blastoma. This HIFU approach transforms immunologically 'cold' tumors into responsive 'hot' tumors. This therapeutic approach is non-invasive and can effectively induce immune sensitization in solid tumors and promises a novel yet efficacious immuno-adjuvant modality to overcome therapeutic resistance.This device-drug combination can also be tested for multiple solid tumor types, and potentially betailored for patient specific therapy. I will also, concisely, present my prior work in developing and translating novel diagnostic ultrasound-based shearwave elastography (SWE) in measuring placental stiffness in patients suffering from preeclampsia, as well as in patients suffering from musculoskeletal disorders.

Location Conference Hall, Network Building

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